Involvement of the motor cortex in pseudochoreoathetosis
Identifieur interne : 004768 ( Main/Exploration ); précédent : 004767; suivant : 004769Involvement of the motor cortex in pseudochoreoathetosis
Auteurs : Lars Timmermann [Allemagne] ; Joachim Gross [Allemagne] ; Frank Schmitz [Allemagne] ; Hans-Joachim Freund [Allemagne] ; Alfons Schnitzler [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Athetosis (etiology), Athetosis (physiopathology), Case study, Case-Control Studies, Chorea (etiology), Chorea (physiopathology), Choreoathetosis, Electromyography, Exploration, Female, Hand, Humans, MEG, Magnetoencephalography, Male, Middle Aged, Motor Cortex (physiopathology), Motor Neurons, Motor cortex, Muscle, Skeletal (physiopathology), Pseudochoreoathetosis, Psychomotor Performance, Sensation Disorders (etiology), Upper limb, coherence, corticomotoneuronal, deafferentation, finger movements.
- MESH :
- etiology : Athetosis, Chorea, Sensation Disorders.
- physiopathology : Athetosis, Chorea, Motor Cortex, Muscle, Skeletal.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Electromyography, Female, Hand, Humans, Magnetoencephalography, Male, Middle Aged, Motor Neurons, Psychomotor Performance.
Abstract
The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1180
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-09">2001-09</date><biblScope unit="vol">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="876">876</biblScope><biblScope unit="page" to="881">881</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5C46B19921B0DC658658D3BE3445A5213C4281F2</idno><idno type="DOI">10.1002/mds.1180</idno><idno type="ArticleID">MDS1180</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Athetosis (etiology)</term><term>Athetosis (physiopathology)</term><term>Case study</term><term>Case-Control Studies</term><term>Chorea (etiology)</term><term>Chorea (physiopathology)</term><term>Choreoathetosis</term><term>Electromyography</term><term>Exploration</term><term>Female</term><term>Hand</term><term>Humans</term><term>MEG</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Motor Neurons</term><term>Motor cortex</term><term>Muscle, Skeletal (physiopathology)</term><term>Pseudochoreoathetosis</term><term>Psychomotor Performance</term><term>Sensation Disorders (etiology)</term><term>Upper limb</term><term>coherence</term><term>corticomotoneuronal</term><term>deafferentation</term><term>finger movements</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Athetosis</term><term>Chorea</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Athetosis</term><term>Chorea</term><term>Motor Cortex</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Electromyography</term><term>Female</term><term>Hand</term><term>Humans</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term><term>Motor Neurons</term><term>Psychomotor Performance</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Choréoathétose</term><term>Cortex moteur</term><term>Electromyographie</term><term>Etude cas</term><term>Exploration</term><term>Femelle</term><term>Magnétoencéphalographie</term><term>Main</term><term>Membre supérieur</term><term>Mâle</term><term>Pseudochoréoathétose</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age‐matched controls cortical activity with a whole‐head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG‐EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG‐EMG coherence in patients was similar to that of controls. Cortical sources of MEG‐EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG‐EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation. © 2001 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></noRegion><name sortKey="Freund, Hans Oachim" sort="Freund, Hans Oachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name><name sortKey="Gross, Joachim" sort="Gross, Joachim" uniqKey="Gross J" first="Joachim" last="Gross">Joachim Gross</name><name sortKey="Schmitz, Frank" sort="Schmitz, Frank" uniqKey="Schmitz F" first="Frank" last="Schmitz">Frank Schmitz</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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